Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development

@article{Eischen2004LossOO,
  title={Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development},
  author={Christine M. Eischen and Jodi R. Alt and Peng Wang},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={8931-8940}
}
The tumor suppressor p19ARF inhibits Mdm2, which restricts the activity of p53. Complicated feedback and control mechanisms regulate ARF, Mdm2, and p53 interactions. Here we report that ARF haploinsufficiency completely rescued the p53-dependent effects of Mdm2 haploinsufficiency on B-cell development, survival, and transformation. In contrast to Mdm2+/− B cells, Mdm2+/− B cells deficient in ARF were similar to wild-type B cells in their rates of growth and apoptosis and activation of p53… CONTINUE READING