Loss of nuclear p27 expression and its prognostic role in relation to cyclin E and p53 mutation in gastroenteropancreatic neuroendocrine tumors.

@article{Grabowski2008LossON,
  title={Loss of nuclear p27 expression and its prognostic role in relation to cyclin E and p53 mutation in gastroenteropancreatic neuroendocrine tumors.},
  author={Patricia Grabowski and Joerg Schrader and Julia Wagner and Dieter Hoersch and Rudolf Arnold and Christian N. Arnold and Inna Georgieva and Harald Stein and Martin Zeitz and Peter T. Daniel and Isrid Sturm},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 22},
  pages={7378-84}
}
PURPOSE Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are classified by the WHO, yet its prognostic value needs to be confirmed. Therefore, we aimed to determine the prognostic role of cell cycle key regulatory genes p53, p27kip1 (p27), and cyclin E in this tumor entity. EXPERIMENTAL DESIGN Tumor specimen from 89 patients with a complete follow-up were studied immunohistochemically for p27 and cyclin E expression and for p53 mutations. The functional relevance of p27 was evaluated in… CONTINUE READING

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