Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration.

@article{Lee2011LossON,
  title={Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration.},
  author={Candy S Lee and Chiashan Lee and Terry Hu and Janice M Nguyen and Jiasheng Zhang and Maureen V. Martin and Marquis P. Vawter and Eric H. Huang and Jefferson Y Chan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 20},
  pages={8408-13}
}
The ubiquitin-proteasome pathway plays an important role in the pathogenesis of neurodegeneration, but mechanisms controlling expression of components in this pathway remain poorly understood. Nuclear factor E2-related factor 1 (Nrf1) transcription factor has been shown to regulate expression of antioxidant and cytoprotective genes. To determine the function of Nrf1 in the brain, mice with a late-stage deletion of Nrf1 in neuronal cells were generated. Loss of Nrf1 leads to impaired proteasome… CONTINUE READING

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