Loss of nuclear expression of the p33(ING1b) inhibitor of growth protein in childhood acute lymphoblastic leukaemia.

@article{Nouman2002LossON,
  title={Loss of nuclear expression of the p33(ING1b) inhibitor of growth protein in childhood acute lymphoblastic leukaemia.},
  author={Ghassan S Nouman and John James Anderson and Katrina M. Wood and John Lunec and Andrew G Hall and M. M. Reid and Brian Angus},
  journal={Journal of clinical pathology},
  year={2002},
  volume={55 8},
  pages={596-601}
}
BACKGROUND/AIMS p33(ING1b) is a tumour suppressor protein involved in growth control and apoptosis. Suppression of p33(ING1b) expression is associated with the loss of cellular growth control and immortalisation, whereas its overexpression causes cell cycle arrest. Moreover, normal p33(ING1b) expression is essential for optimal function of p53. Acute lymphoblastic leukaemia (ALL) is the most common malignancy of childhood, accounting for one third of all childhood malignancies. A variety of… CONTINUE READING
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Comparative assessment of expression of the inhibitor of growth 1 ( ING 1 ) gene in normal amd neoplastic tissues

  • GS Nouman, B Angus, J Lunec
  • Hybridoma and Hybridomics
  • 2002

Inactivation of p 33 ( ING 1 ) tumor suppressor affects the function of the cell cycle “ checkpoints ” and stability of the genome

  • NA Turovets, LS Agapova, PB Kopnin
  • Genetika
  • 2000

Monoclonal antibodies raised to products of the ING 1 tumour suppressor gene locus

  • GS Nouman, B Angus, J Lunec
  • J Pathol
  • 2000

Sequencing of ING 1 tumour suppressor gene cDNAs generated from mRNA recovered from normal and neoplastic cell lines

  • GS Nouman, JJ Anderson, B Angus
  • J Pathol
  • 2000

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