Loss of nuclear PTEN in HCV-infected human hepatocytes

@inproceedings{Bao2013LossON,
  title={Loss of nuclear PTEN in HCV-infected human hepatocytes},
  author={Wenjie Bao and Liliana Florea and Ningbin Wu and Zhao Wang and Krishna K. Banaudha and Jason Qian and Laurent Houzet and Rakesh Kumar and Ajit Kumar},
  booktitle={Infectious Agents and Cancer},
  year={2013}
}
Hepatitis C virus (HCV) infection is a major risk factor for chronic hepatitis and hepatocellular carcinoma (HCC); however, the mechanism of HCV-mediated hepatocarcinogenesis is not well understood. Insufficiency of PTEN tumor suppressor is associated with more aggressive cancers, including HCC. We asked whether viral non-coding RNA could initiate oncogenesis in HCV infected human hepatocytes. The results presented herein suggest that loss of nuclear PTEN in HCV-infected human hepatocytes… CONTINUE READING
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