Loss of notch activity in the developing central nervous system leads to increased cell death.

@article{Mason2006LossON,
  title={Loss of notch activity in the developing central nervous system leads to increased cell death.},
  author={Heather A Mason and Staci M Rakowiecki and Thomas Gridley and Gordon Fishell},
  journal={Developmental neuroscience},
  year={2006},
  volume={28 1-2},
  pages={49-57}
}
Many cells in the mammalian brain undergo apoptosis as a normal and critical part of development but the signals that regulate the survival and death of neural progenitor cells and the neurons they produce are not well understood. The Notch signaling pathway is involved in multiple decision points during development and has been proposed to regulate the survival and apoptosis of neural progenitor cells in the developing brain; however, previous experiments have not resolved whether Notch… CONTINUE READING

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