Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris.

@article{Presland2000LossON,
  title={Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris.},
  author={Richard B. Presland and Dawnalyn Boggess and Shane P. Lewis and Court Hull and Philip H Fleckman and John P. Sundberg},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={115 6},
  pages={1072-81}
}
Flaky tail (gene symbol ft) is an autosomal recessive mutation in mice that results in a dry, flaky skin, and annular tail and paw constrictions in the neonatal period. Previous studies demonstrated that the ft mutation maps to the central region of mouse chromosome 3, in the vicinity of the epidermal differentiation complex, a gene locus that includes many nonkeratin genes expressed in epidermis. In this study we report a detailed characterization of the flaky tail mouse. Affected homozygous… CONTINUE READING
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