Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity.

@article{Opland2013LossON,
  title={Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity.},
  author={Darren M. Opland and Amy Sutton and Hillary L Woodworth and Juliette Brown and Raluca Bugescu and Adriana Garc{\'i}a and Lyndsay Christensen and Christopher N Rhodes and Martin M. Myers and Gina M Leinninger},
  journal={Molecular metabolism},
  year={2013},
  volume={2 4},
  pages={423-34}
}
Neurons of the lateral hypothalamic area (LHA) control motivated behaviors such as feeding and ambulatory activity, in part by modulating mesolimbic dopamine (DA) circuits. The hormone, leptin, acts via the long form of the leptin receptor (LepRb) in the brain to signal the repletion of body energy stores, thereby decreasing feeding and promoting activity. LHA LepRb neurons, most of which contain neurotensin (Nts; LepRb(Nts) neurons) link leptin action to the control of mesolimbic DA function… CONTINUE READING
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