Loss of naïve cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques.

@article{Nishimura2007LossON,
  title={Loss of na{\"i}ve cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques.},
  author={Yoshiaki Toyota-shi Aichi-ken Nishimura and Tatsuhiko Igarashi and Alicia J. Buckler-White and Charles E. Buckler and Hiromi Imamichi and Robert M Goeken and Wendy R. Lee and Bernard A Lafont and Russ Byrum and H. Clifford Lane and Vanessa M Hirsch and Malcolm A Martin},
  journal={Journal of virology},
  year={2007},
  volume={81 2},
  pages={
          893-902
        }
}
Human immunodeficiency virus and simian immunodeficiency virus (SIV) induce a slow progressive disease, characterized by the massive loss of memory CD4+ T cells during the acute infection followed by a recovery phase in which virus replication is partially controlled. However, because the initial injury is so severe and virus production persists, the immune system eventually collapses and a symptomatic fatal disease invariably occurs. We have assessed CD4+ T-cell dynamics and disease… CONTINUE READING
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Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection

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