Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney.

Abstract

The kidney's filtration activity is essential for removing toxins and waste products from the body. The vascular endothelial cells of the glomerulus are fenestrated, flattened, and surrounded by podocytes, specialized cells that support glomerular endothelial cells. Mucin-type core 1-derived O-glycans (O-glycans) are highly expressed on both glomerular… (More)
DOI: 10.1074/jbc.M117.798512

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