Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells.

@article{InayatHussain2003LossOM,
  title={Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells.},
  author={Salmaan H. Inayat-Hussain and B O Annuar and Laily Bin Din and A. Mubarak Ali and David D. Ross},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2003},
  volume={17 4},
  pages={433-9}
}
Styryl-lactones such as goniothalamin represent a new class of compounds with potential anti-cancer properties. In this study, we investigated the mechanisms of goniothalamin (GTN), a plant styryl-lactone induced apoptosis in human promyelocytic leukemia HL-60 cells. This plant extract resulted in apoptosis in HL-60 cells as assessed by the externalisation of phosphatidylserine. Using the mitochondrial membrane dye (DIOC(6)) in conjunction with flow cytometry, we found that GTN treated HL-60… CONTINUE READING
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Cell cycle and apoptosis induction by goniothalamin in CEM-SS T-lymphoblastic leukemia cell line

  • A. M. Ali, N. Umar-Tsafe, +6 authors S. H. Inayat-Hussain
  • Journal of Biochemistry, Molecular Biology and…
  • 2000
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