Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.

@article{Rogan2004LossOM,
  title={Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.},
  author={Mark P. Rogan and Clifford C. Taggart and Catherine M Greene and Philip M Murphy and Shane J. O'neill and Noel Gerry McElvaney},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={190 7},
  pages={
          1245-53
        }
}
Intractable formation of biofilm by and infection with the opportunistic pathogen Pseudomonas aeruginosa are hallmarks of cystic fibrosis (CF). Lactoferrin, an innate immunity protein, has recently been shown to inhibit the formation of P. aeruginosa biofilm. Partial cleavage of lactoferrin by the proteases neutrophil elastase and Pseudomonas elastase has previously been described in CF. Here, we show that cathepsins in CF secretions are responsible for complete and rapid cleavage of… CONTINUE READING
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