Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

@article{Hbert2008LossOM,
  title={Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.},
  author={S{\'e}bastien S. H{\'e}bert and Katri{\'e}n Horr{\'e} and Laura J J Nicola{\"i} and Aikaterini S. Papadopoulou and Wim J. Mandemakers and Asli Silahtaroglu and Sakari Kauppinen and Andr{\'e} Delacourte and Bart De Strooper},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 17},
  pages={6415-20}
}
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms affecting Abeta generation in sporadic AD. Deficiency in Abeta clearance is certainly a possibility, but increased expression of proteins like APP or BACE1/beta-secretase may also be associated with the disease. We therefore investigated changes in microRNA (miRNA) expression profiles of sporadic AD patients and found that several miRNAs… CONTINUE READING
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