Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CDC28 protein kinase regulatory subunit 1B

@inproceedings{Hu2016LossOM,
  title={Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CDC28 protein kinase regulatory subunit 1B},
  author={Minghua Hu and Mingwei Wang and Huihong Lu and Xiaoming Wang and Xiaoshan Fang and Jinguo LiuandYuechao Wang and Chenyang Ma and Xiaobing Chen and Hongping Xia},
  booktitle={Oncotarget},
  year={2016}
}
Hepatocellular carcinoma (HCC) is the leading cause of cancer related death worldwide. The number of deaths is proportional to the global incidence, which highlights the aggressive tumor biology and lack of effective therapies. Dysregulation of microRNAs has been implicated in carcinogenesis and progression of liver cancer. Here, we identified that miR-1258 was significantly downregulated in HCC and associated with poor patients' survival. Overexpression of miR-1258 significantly inhibits liver… CONTINUE READING
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