Loss of menin in osteoblast lineage affects osteocyte–osteoclast crosstalk causing osteoporosis


During osteoporosis bone formation by osteoblasts is reduced and/or bone resorption by osteoclasts is enhanced. Currently, only a few factors have been identified in the regulation of bone integrity by osteoblast-derived osteocytes. In this study, we show that specific disruption of menin, encoded by multiple endocrine neoplasia type 1 (Men1), in… (More)
DOI: 10.1038/cdd.2016.165