Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance

@article{Zwaal1989LossOM,
  title={Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance},
  author={Robert F. A. Zwaal and Edouard M. Bevers and Paul Comfurius and Jan Rosing and Roland H. J. Tilly and Peter F. J. Verhallen},
  journal={Molecular and Cellular Biochemistry},
  year={1989},
  volume={91},
  pages={23-31}
}
Membrane phospholipid asymmetry is considered to be a general property of biological membranes. Detailed information is presently available on the non-random orientation of phospholipids in red cell- and platelet membranes. The outer leaflet of the lipid bilayer membrane is rich in choline-phospholipids, whereas amino-phospholipids are abundant in the inner leaflet. Studies with blood platelets have shown that these asymmetries are not maintained when the cells are activated in various ways… CONTINUE READING
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