Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance

@article{Zwaal2004LossOM,
  title={Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance},
  author={R. Zwaal and E. Bevers and P. Comfurius and J. Rosing and R. H. Tilly and P. Verhallen},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={91},
  pages={23-31}
}
  • R. Zwaal, E. Bevers, +3 authors P. Verhallen
  • Published 2004
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • Membrane phospholipid asymmetry is considered to be a general property of biological membranes. Detailed information is presently available on the non-random orientation of phospholipids in red cell- and platelet membranes. The outer leaflet of the lipid bilayer membrane is rich in choline-phospholipids, whereas amino-phospholipids are abundant in the inner leaflet. Studies with blood platelets have shown that these asymmetries are not maintained when the cells are activated in various ways… CONTINUE READING
    Increased exposure of anionic phospholipids on the surface of tumor blood vessels.
    • 383
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 30 REFERENCES
    Localization of red cell membrane constituents.
    • 376