Loss of membrane excitability after herpes simplex virus infection in tissue-cultured nerve cells from adult mammals

@article{Fukuda1981LossOM,
  title={Loss of membrane excitability after herpes simplex virus infection in tissue-cultured nerve cells from adult mammals},
  author={Jinichi Fukuda and T. Kurata},
  journal={Brain Research},
  year={1981},
  volume={211},
  pages={235-241}
}
Dorsal root ganglion cells of adult guinea-pigs in vitro were inoculated with herpes simplex virus (HSV). Intracellular recording with a glass microelectrode revealed that HSV-infection caused a marked decrease in membrane excitability of the nerve cells within 24 h, which could be explained as a decrease in Na+ channel activity in the plasma membrane; while changes in other physiological properties (resting membrane potential, membrane resistance and capacitance) remain small. Viral antigens… CONTINUE READING
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