Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia

@article{Taketomi2005LossOM,
  title={Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia},
  author={Takaharu Taketomi and Daigo Yoshiga and Koji Taniguchi and Takashi Kobayashi and Atsushi Nonami and Reiko Kato and Mika Sasaki and Atsuo Sasaki and Hitoshi Ishibashi and Maiko Moriyama and Kei-ichiro Nakamura and Junji Nishimura and Akihiko Yoshimura},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={855-857}
}
We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction. Glial cell line–derived neurotrophic factor (GDNF) induced hyperactivation of ERK and Akt in enteric nerve cells. Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve… CONTINUE READING

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Nature Neuroscience Volume

  • K. Shim, G. Minowada, D. E. Coling, Martin, G. R. Dev
  • Cell
  • 2005

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