Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice.

@article{Friedman2010LossOL,
  title={Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice.},
  author={James S. Friedman and B. -Y. Chang and Daniel S Krauth and Irma L{\'o}pez and Naushin H. Waseem and Ron E Hurd and Kecia L Feathers and Kari E. H. Branham and Manessa Shaw and George E C Thomas and Matthew John Brooks and Chunqiao Liu and Hirva A Bakeri and Maria Mercedes Campos and C{\'e}cilia Maubaret and Andrew R. Webster and Ignacio R. Rodriguez and Debra A. Thompson and Shomi Shanker Bhattacharya and Robert Koenekoop and John R. Heckenlively and Anand Swaroop},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 35},
  pages={15523-8}
}
Retinal degenerative diseases, such as retinitis pigmentosa and Leber congenital amaurosis, are a leading cause of untreatable blindness with substantive impact on the quality of life of affected individuals and their families. Mouse mutants with retinal dystrophies have provided a valuable resource to discover human disease genes and helped uncover pathways critical for photoreceptor function. Here we show that the rd11 mouse mutant and its allelic strain, B6-JR2845, exhibit rapid… CONTINUE READING
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