Loss of intracellular putrescine pool-size regulation induces apoptosis.

@article{Xie1997LossOI,
  title={Loss of intracellular putrescine pool-size regulation induces apoptosis.},
  author={Xitao Xie and Margaret E Tome and Eugene W. Gerner},
  journal={Experimental cell research},
  year={1997},
  volume={230 2},
  pages={386-92}
}
Synthesis and uptake are two important regulated mechanisms by which eukaryotic cells maintain polyamine levels. The role that loss of synthesis and/or uptake regulation plays in mediating putrescine toxicity was investigated by comparing toxicity in an ornithine decarboxylase (ODC)-deficient Chinese hamster ovary cell line (C55.7) with a functional putrescine transport system and an ODC-overproducing rat hepatoma cell line (DH23b), which are transport regulation deficient. When C55.7 cells… CONTINUE READING