Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.

@article{Morris2003LossOI,
  title={Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.},
  author={David G. Morris and Xiaozhu Huang and Naftali Kaminski and Yanli Wang and Steven D Shapiro and Gregory Dolganov and Adam Glick and Dean Sheppard},
  journal={Nature},
  year={2003},
  volume={422 6928},
  pages={169-73}
}
Integrins are heterodimeric cell-surface proteins that regulate cell growth, migration and survival. We have shown previously that the epithelial-restricted integrin alpha(v)beta6 has another critical function; that is, it binds and activates latent transforming growth factor-beta (TGF-beta). Through a global analysis of pulmonary gene expression in the lungs of mice lacking this integrin (Itgb6 null mice) we have identified a marked induction of macrophage metalloelastase (Mmp12)--a… CONTINUE READING
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