Loss of integration is associated with reduced resistance to oxidative stress.

@article{Costantini2013LossOI,
  title={Loss of integration is associated with reduced resistance to oxidative stress.},
  author={David Costantini and Pat Monaghan and Neil B. Metcalfe},
  journal={The Journal of experimental biology},
  year={2013},
  volume={216 Pt 12},
  pages={2213-20}
}
One cellular mechanism thought to be particularly important as a constraint on lifespan and life-history strategies is oxidative stress. Susceptibility to oxidative stress is influenced by a number of antioxidant defences, whose effectiveness depends on the synergistic and competitive interactions among them (biochemical integration). It is generally assumed that exposure to oxidative stress is detrimental, but it is also possible that low level oxidative stress has a positive effect on… CONTINUE READING

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