Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

@article{Michael2000LossOI,
  title={Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.},
  author={Mervyn Dodson Michael and Rohit N. Kulkarni and Catherine Postic and Stephen F. Previs and Gerald I Shulman and Mark A Magnuson and C Ronald Kahn},
  journal={Molecular cell},
  year={2000},
  volume={6 1},
  pages={87-97}
}
The liver plays a central role in the control of glucose homeostasis and is subject to complex regulation by substrates, insulin, and other hormones. To investigate the effect of the loss of direct insulin action in liver, we have used the Cre-loxP system to inactivate the insulin receptor gene in hepatocytes. Liver-specific insulin receptor knockout (LIRKO) mice exhibit dramatic insulin resistance, severe glucose intolerance, and a failure of insulin to suppress hepatic glucose production and… CONTINUE READING
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