Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology.

@article{Kurumatani1998LossOI,
  title={Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology.},
  author={T. Kurumatani and Johan Fastbom and Willy L Bonkale and Nenad Bogdanovi{\'c} and Bengt Winblad and Thomas Georg Ohm and Richard F. Cowburn},
  journal={Brain research},
  year={1998},
  volume={796 1-2},
  pages={209-21}
}
Inositol 1,4,5-trisphosphate (IP3), inositol 1,3,4,5-tetrakisphosphate (IP4) and protein kinase C (PKC) play important roles in the phosphoinositide hydrolysis signal transducing pathway. Several studies have shown severe deficits in both IP3 receptor levels and PKC levels and activity in Alzheimer's disease brain, although the relationship of these changes to disease pathology is poorly understood. In the present study, we determined the autoradiographic localization of [3H]IP3 and [3H]IP4… CONTINUE READING

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