Loss of inhibitory neuron AMPA receptors contributes to ataxia and epilepsy in stargazer mice.

@article{Menuz2008LossOI,
  title={Loss of inhibitory neuron AMPA receptors contributes to ataxia and epilepsy in stargazer mice.},
  author={Karen Menuz and Roger A Nicoll},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 42},
  pages={10599-603}
}
Stargazer mice are characterized by ataxia and seizures, which resemble the human disorder absence epilepsy. Stargazin, the protein mutated in stargazer mice, promotes the expression and function of neuronal AMPA receptors (AMPARs). However, it is unclear how decreased expression of excitatory AMPARs generates stargazer seizures, given that seizures often result from increased neuronal excitability. Additionally, although stargazer ataxia has been attributed to loss of AMPARs from cerebellar… CONTINUE READING