Loss-of-imprinting of Peg1 in mouse interspecies hybrids is correlated with altered growth.

@article{Shi2004LossofimprintingOP,
  title={Loss-of-imprinting of Peg1 in mouse interspecies hybrids is correlated with altered growth.},
  author={Wei W. Shi and Louis A. Lefebvre and Yang Yu and Sabine Otto and Antje Krella and Annie Orth and Reinald H. Fundele},
  journal={Genesis},
  year={2004},
  volume={39 1},
  pages={65-72}
}
Previous studies have shown that loss-of-imprinting (LOI) is a regular occurrence in interspecies hybrids of the genus Peromyscus. Furthermore, evidence was presented that indicated that LOI is involved in a placental hybrid dysgenesis effect resulting in abnormal placental growth and thus possibly in speciation. We show here that LOI of the strictly paternally expressed gene Peg1 (also called Mest) occurs in F1 hybrids between Mus musculus (MMU) and M. spretus (MSP). Peg1 LOI is correlated… CONTINUE READING

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