Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration.

@article{Tamai2008LossOH,
  title={Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration.},
  author={Keiichi Tamai and Masafumi Toyoshima and Nobuyuki Tanaka and Noriko Yamamoto and Yuji Owada and Hiroshi Kiyonari and Kazuko Murata and Yoshiyuki Ueno and Masao Ono and Tooru Shimosegawa and Nobuo Yaegashi and Masahiko Watanabe and Kazuo Sugamura},
  journal={The American journal of pathology},
  year={2008},
  volume={173 6},
  pages={
          1806-17
        }
}
The endosomal sorting complex required for transport (ESCRT) proteins form multimolecular complexes that control multivesicular body formation, endosomal sorting, and transport ubiquitinated membrane proteins (including cell-surface receptors) to the endosomes for degradation. There is accumulating evidence that endosomal dysfunction is linked to neural cell degeneration in vitro, but little is known about the relationship between neural disorders and ESCRT proteins in vivo. Here we… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons

  • Molecular and Cellular Neuroscience
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells.

  • Biochemical and biophysical research communications
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

AMSH is required to degrade ubiquitinated proteins in the central nervous system.

  • Biochemical and biophysical research communications
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

  • Molecular Neurodegeneration
  • 2008
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND

Similar Papers

Loading similar papers…