Loss of homotypic epithelial cell adhesion by selective N-cadherin displacement in bismuth nephrotoxicity.

@article{Leussink2001LossOH,
  title={Loss of homotypic epithelial cell adhesion by selective N-cadherin displacement in bismuth nephrotoxicity.},
  author={Berend T. Leussink and Sergey V. Litvinov and Emile de Heer and Anja Slikkerveer and Gijsbert B. van der Voet and Jan Anthonie Bruijn and Frederik A de Wolff},
  journal={Toxicology and applied pharmacology},
  year={2001},
  volume={175 1},
  pages={54-9}
}
The nephrotoxicity of single high doses of bismuth (Bi)-containing therapeutic drugs is characterized morphologically by detachment of proximal tubular epithelial cells (PTECs) from each other, followed by cell death. We investigated whether Bi nephrotoxicity is mediated by changes in the distribution of proteins involved in intercellular adhesion. A nephrotoxic dose of colloidal bismuth subcitrate (CBS; 3.0 mmol Bi/kg) was orally administrated to 10 female Wistar rats. After 1 h, N-cadherin… CONTINUE READING

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