Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma.

  title={Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma.},
  author={L. F. Hu and Gudny Eir{\'i}ksdott{\'i}r and Tatjana Lebedeva and I Kholodniouk and Andrei Alimov and Erwei Song and Yuan-hui Luo and Eugene R. Zabarovsky and Sigurður Ingvarsson and George Klein and Ingemar Ernberg},
  journal={Genes, chromosomes & cancer},
  volume={17 2},
We have examined 17 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte DNA from the same patients. Ten polymorphic microsatellite markers were used between 3p13 and 3p26. Allelic loss was observed in 12 samples (70%). Two loci were most frequently affected: D3S1067 (3p21.1-14.3) in 60% and D3S1217 (3p14.2-14.1) in 58%. One tumor seemed to have a homozygous deletion at 3p26, detected by the D3S1297… CONTINUE READING


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A major role for a 3 p 21 region and lack of involvement of the t ( 3 ; 8 ) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis

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