Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas.

@article{Ehlen1990LossOH,
  title={Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas.},
  author={Thomas G. Ehlen and Louis Dubeau},
  journal={Oncogene},
  year={1990},
  volume={5 2},
  pages={219-23}
}
The genetic events involved in human ovarian carcinoma development are still largely unknown. We have used DNA recombinant technologies to examine the genome of normal and neoplastic tissues from 12 different patients with such tumors. We used cloned DNA sequences homologous to loci showing restriction fragment length polymorphisms on chromosomal segments 3p, 5p, 6q, 11p, or 21q to determine the frequencies of losses of constitutional heterozygosity at these loci in tumor DNAs. Losses affecting… CONTINUE READING

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