Loss of heterozygosity of the Wilms' tumor suppressor gene (WT1) in in situ and invasive breast carcinoma.

@article{Fabre1999LossOH,
  title={Loss of heterozygosity of the Wilms' tumor suppressor gene (WT1) in in situ and invasive breast carcinoma.},
  author={Aur{\'e}lie Fabre and Amanda H McCann and Derville O'Shea and Dennise Broderick and George Keating and Brendan Tobin and Tom Gorey and Peter A. Dervan},
  journal={Human pathology},
  year={1999},
  volume={30 6},
  pages={661-5}
}
The Wilms' tumor suppressor gene (WT1), a nuclear transcription factor, regulates the expression of the insulin-like growth factor (IGF) and transforming growth factor (TGF) systems, both of which are implicated in breast tumorigenesis. WT1 allelic integrity was examined by loss of heterozygosity (LOH) studies in formalin-fixed, paraffin-embedded (FFPE) ductal carcinoma in situ (DCIS, n = 20) and fresh frozen primary invasive breast carcinomas (n = 24). Loss of heterozygosity (LOH) at the WT1… CONTINUE READING