Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors.

@article{Takebayashi2001LossOH,
  title={Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors.},
  author={Yuji Takebayashi and Kentaro Nakayama and Atsuko Kanzaki and Hitoshi Miyashita and Osamu Ogura and Shoichi Mori and Michihiro Mutoh and Kou Miyazaki and Manabu Fukumoto and Yves Pommier},
  journal={Cancer letters},
  year={2001},
  volume={174 2},
  pages={115-25}
}
The deficiencies of nucleotide excision repair (NER) factors are genetic diseases, xeroderma pigmentosum (XP) increasing risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (LOH) analysis for the XP, XPA, XPB, XPC, XPD, XPE, XPF, XPG and the transcription-coupled repair factor, Cockayne syndrome B (CSB) revealed that NER factors were abnormal in 62.1 % of ovarian tumors (18/29… CONTINUE READING