Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

  title={Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer},
  author={S. L. Naylor and Bruce Evan Johnson and John D. Minna and Alan Y. Sakaguchi},
Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14)1 and Wilm's tumour (chromosome 11p13)2 have led to the hypothesis that recessive genes may be involved in tumorigenesis3. This hypothesis is supported by demonstration of allele loss specific for these regions using polymorphic DNA markers4–9 and by the isolation of a complementary DNA clone for the retinoblastoma gene10. A cytogenetic deletion in chromosome 3 (p14–p23) was reported in… CONTINUE READING

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