Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain.

@article{Blackburn2004LossOH,
  title={Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain.},
  author={Anneke C Blackburn and S Christine McLary and Rizwan Naeem and Jason Luszcz and David Stockton and Lawrence A. Donehower and Mansoor Mohammed and John B. Mailhes and Tamar Soferr and Stephen P. Naber and Christopher N Otis and D Joseph Jerry},
  journal={Cancer research},
  year={2004},
  volume={64 15},
  pages={5140-7}
}
Loss of heterozygosity (LOH) occurs commonly in cancers causing disruption of tumor suppressor genes and promoting tumor progression. BALB/c-Trp53(+/-) mice are a model of Li-Fraumeni syndrome, exhibiting a high frequency of mammary tumors and other tumor types seen in patients. However, the frequency of mammary tumors and LOH differs among strains of Trp53(+/-) mice, with mammary tumors occurring only on a BALB/c genetic background and showing a high frequency of LOH, whereas Trp53(+/-) mice… CONTINUE READING

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