Loss of heterozygosity in chromosomal region 16q24.3 associated with progression of prostate cancer.

@article{Hrknen2005LossOH,
  title={Loss of heterozygosity in chromosomal region 16q24.3 associated with progression of prostate cancer.},
  author={P{\"a}ivi H{\"a}rk{\"o}nen and Atte P. Kyll{\"o}nen and Stig Nordling and Pirkko Vihko},
  journal={The Prostate},
  year={2005},
  volume={62 3},
  pages={267-74}
}
BACKGROUND The molecular mechanisms underlying the development and progression of prostate cancer have remained poorly understood. To find out potential genetic markers likely to underlie tumor progression, the pattern of allelic loss on chromosome arm 16q in matched primary, locally recurrent, and metastatic prostate cancer specimens was analyzed in the present study. METHODS The frequency of loss of heterozygosity (LOH) in 74 tumor specimens (62 primary cancer foci and 12 metastatic tumors… CONTINUE READING

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