Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis.

@article{Irving2005LossOH,
  title={Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis.},
  author={J. E. Irving and Lisa Bloodworth and Nick P Bown and Marian C Case and Linda A. Hogarth and Andrew G Hall},
  journal={Cancer research},
  year={2005},
  volume={65 8},
  pages={3053-8}
}
Loss of heterozygosity (LOH) is detectable in many forms of malignancy, including leukemia, using techniques such as microsatellite analysis and comparative genomic hybridization. However, these techniques are laborious and require the use of relatively large amounts of DNA if the whole genome is to be examined. Here we describe the use of oligonucleotide microarrays to characterize single nucleotide polymorphisms (SNPs) in lymphoblasts isolated from children with acute lymphoblastic leukemia… CONTINUE READING