Loss of heterozygosity events impeding breast cancer metastasis contain the MTA1 gene.

  title={Loss of heterozygosity events impeding breast cancer metastasis contain the MTA1 gene.},
  author={Michelle E. D. Martin and Karl von Fischbach and Charles Osborne and Syed Khalid Mohsin and Donald Craig Allred and Peter O'Connell},
  journal={Cancer research},
  volume={61 9},
Breast cancer mortality is seldom attributable to the primary tumor, but rather to the presence of systemic (metastatic) disease. Axillary lymph node dissection can identify the presence of metastatic breast cancer cells and serves as a marker for systemic disease. Previous work in our laboratory determined that rates of loss of heterozygosity (LOH) of a 1.6-Mb region of chromosome 14q 31.2 is much higher in axillary lymph node-negative primary breast tumors than in axillary lymph node-positive… CONTINUE READING
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