Loss of heterozygosity at the FLCN locus in early renal cystic lesions in dogs with renal cystadenocarcinoma and nodular dermatofibrosis

@article{Bnsdorff2009LossOH,
  title={Loss of heterozygosity at the FLCN locus in early renal cystic lesions in dogs with renal cystadenocarcinoma and nodular dermatofibrosis},
  author={Tina B. B\onsdorff and Johan Jansen and Ragnar F. Thomassen and Frode Lingaas},
  journal={Mammalian Genome},
  year={2009},
  volume={20},
  pages={315-320}
}
Small, macroscopically visible cysts on the surface of the kidneys were observed in eight 6–8-week-old puppies diagnosed with renal cystadenocarcinoma and nodular dermatofibrosis (RCND). Histologic examination of the renal cortices in these puppies reveals numerous small cystic tubular changes. Hyperplastic change of the epithelial lining of cysts is frequently observed. By laser-capture microdissection we have sampled epithelial cells from such early renal cystic lesions in eight paternal half… CONTINUE READING

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