Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence.

@article{Thiagalingam2002LossOH,
  title={Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence.},
  author={Sam Thiagalingam and Rebecca L. Foy and Kuang-Hung Cheng and Hyunjoo Lee and Arunthathi Thiagalingam and Jose F. Ponte},
  journal={Current opinion in oncology},
  year={2002},
  volume={14 1},
  pages={65-72}
}
High frequency of chromosomal deletions elicited as losses of heterozygosity is a hallmark of genomic instability in cancer. Functional losses of tumor suppressor genes caused by loss of heterozygosity at defined regions during clonal selection for growth advantage define the minimally lost regions as their likely locations on chromosomes. Loss of heterozygosity is elicited at the molecular or cytogenetic level as a deletion, a gene conversion, single or double homologous and nonhomologous… CONTINUE READING