Loss of heterozygosity and p53 expression in Pterygium.

@article{Reisman2004LossOH,
  title={Loss of heterozygosity and p53 expression in Pterygium.},
  author={David Reisman and Jennifer Wallace McFadden and Gary Lu},
  journal={Cancer letters},
  year={2004},
  volume={206 1},
  pages={77-83}
}
While the pathogenesis of pterygium is still not well understood, environmental factors such at UV light, appear to play an important role in its development. UV radiation can cause mutations in genes such as the p53 tumor suppressor gene, that when inactivated through mutation and loss of heterozygosity can lead to cell proliferation and genomic instability. However, aside from mutations in the gene, other mechanisms have been identified that can lead to loss of p53 function. These include the… CONTINUE READING

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