Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands.

@article{Yamamoto1996LossOH,
  title={Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands.},
  author={Yumi Eguchi Yamamoto and Arvind Kumar Virmani and Ignacio I. Wistuba and Donald D. McIntire and Frank Vuitch and J Albores-saavedra and A. F. Gazdar},
  journal={Human pathology},
  year={1996},
  volume={27 11},
  pages={
          1204-10
        }
}
Adenoid cystic carcinomas (ACC) constitute approximately 20% of malignant salivary gland tumors. Several histological types of ACC are recognized and may coexist in a single tumor. The authors divided ACC into lower grade (tubular and cribriform subtypes) and higher grade (trabecular and solid) subtypes. A preliminary analysis of 10 ACCs showed a relatively high incidence of loss of heterozygosity (LOH) at the p53 and RB genes and low or absent K-ras mutations and LOH at chromosomal loci 3p, 5q… CONTINUE READING
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