Loss of heterozygosity (LOH) profiles--validated risk predictors for progression to oral cancer.

@article{Zhang2012LossOH,
  title={Loss of heterozygosity (LOH) profiles--validated risk predictors for progression to oral cancer.},
  author={Lewei Zhang and Catherine F Poh and Michele Williams and Denise M Laronde and Ken W. Berean and Pamela J Gardner and Huijun Jiang and Lang Wu and J Jack Lee and Miriam Pearl Rosin},
  journal={Cancer prevention research},
  year={2012},
  volume={5 9},
  pages={1081-9}
}
A major barrier to oral cancer prevention has been the lack of validated risk predictors for oral premalignant lesions (OPL). In 2000, we proposed a loss of heterozygosity (LOH) risk model in a retrospective study. This paper validated the previously reported LOH profiles as risk predictors and developed refined models via the largest longitudinal study to date of low-grade OPLs from a population-based patient group. Analysis involved a prospective cohort of 296 patients with primary mild… CONTINUE READING
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