Loss of heterozygosity (LOH) profiles--validated risk predictors for progression to oral cancer.

  title={Loss of heterozygosity (LOH) profiles--validated risk predictors for progression to oral cancer.},
  author={Lewei Zhang and Catherine F Poh and Michele Williams and Denise M Laronde and Ken W. Berean and Pamela J Gardner and Huijun Jiang and Lang Wu and J Jack Lee and Miriam Pearl Rosin},
  journal={Cancer prevention research},
  volume={5 9},
A major barrier to oral cancer prevention has been the lack of validated risk predictors for oral premalignant lesions (OPL). In 2000, we proposed a loss of heterozygosity (LOH) risk model in a retrospective study. This paper validated the previously reported LOH profiles as risk predictors and developed refined models via the largest longitudinal study to date of low-grade OPLs from a population-based patient group. Analysis involved a prospective cohort of 296 patients with primary mild… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 6 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 38 extracted citations

Individualized five-year risk assessment for oral premalignant lesion progression to cancer.

Oral surgery, oral medicine, oral pathology and oral radiology • 2017
View 13 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 28 references

Cancer and ageing: convergent and divergent mechanisms

Nature Reviews Molecular Cell Biology • 2007
View 6 Excerpts
Highly Influenced

The cetuximab for treatment of high-risk premalignant upper aerodigestive lesions trial

Lewei Zhang, Catherine F. Poh, Michele Williams
Cancer Prev Res; • 2011
View 1 Excerpt

An INKlination for epigenetic control of senescence

Nature Structural &Molecular Biology • 2008

Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics • 2006

Similar Papers

Loading similar papers…