Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis.

@article{Pelletier2010LossOH,
  title={Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis.},
  author={Laura Pelletier and Sandra Rebouissou and Alain Louveau Paris and Estelle Rathahao-Paris and Elisabeth Perdu and Paulette Bioulac-Sage and Sandrine Imbeaud and Jessica Zucman-Rossi},
  journal={Hepatology},
  year={2010},
  volume={51 2},
  pages={
          557-66
        }
}
UNLABELLED Hepatocellular adenomas (HCAs) are benign liver tumors that usually develop in women who are taking oral contraceptives. Among these tumors, biallelic inactivating mutations of the hepatocyte nuclear factor 1alpha (HNF1A) transcription factor have been frequently identified and in rare cases of hepatocellular carcinomas developed in noncirrhotic liver. Because HNF1A meets the genetic criteria of a tumor suppressor gene, we aimed to elucidate the tumorigenic mechanisms related to… CONTINUE READING
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Association of CYP1B1 germ line mutations with hepatocyte nuclear fac HEPATOLOGY

  • E Jeannot, K Poussin, L Chiche, Y Bacq, N Sturm, JY Scoazec
  • Cancer Res
  • 2010

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