Loss of glycine-dependent radioligand binding to the N-methyl-D-aspartate-phencyclidine receptor complex in patients with Alzheimer's disease.

@article{Procter1989LossOG,
  title={Loss of glycine-dependent radioligand binding to the N-methyl-D-aspartate-phencyclidine receptor complex in patients with Alzheimer's disease.},
  author={Andrew W. Procter and J M Stirling and Gary C. Stratmann and Alan J. Cross and David M. Bowen},
  journal={Neuroscience letters},
  year={1989},
  volume={101 1},
  pages={62-6}
}
Well washed membranes have been prepared from samples of cerebral cortex of control subjects and patients with Alzheimer's disease, obtained both at post mortem and by neurosurgical procedures earlier in the course of the disease. Binding to these membranes of two radioligands for the N-methyl-D-aspartate-phencyclidine receptor complex has been determined in the presence and absence of glycine. Glycine increased the binding in both control and Alzheimer tissue samples. At one concentration of… CONTINUE READING

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