Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.

Abstract

OBJECTIVE The human insulin-like growth factor 2 (IGF2) gene was thought to be imprinted and expressed only from the paternal allele in normal tissue. MATERIALS AND METHODS Initially, we analyzed the imprinting status of IGF2 in bone marrow cells from 49 patients with myelodysplastic syndromes (MDS) utilizing the Apa I polymorphism of IGF2. Thirteen bone… (More)

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@article{Hofmann2002LossOG, title={Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.}, author={Wolf Karsten Hofmann and Seisho Takeuchi and Malka A Frantzen and Dieter Hoelzer and H Phillip Koeffler}, journal={Experimental hematology}, year={2002}, volume={30 4}, pages={318-23} }