Loss of genetic accuracy in mutants of the thermoacidophile Sulfolobus acidocaldarius.

Abstract

To investigate how hyperthermophilic archaea can propagate their genomes accurately, we isolated Sulfolobus acidocaldarius mutants exhibiting abnormally high rates of spontaneous mutation. Our isolation strategy involved enrichment for mutator lineages via alternating selections, followed by screening for the production of spontaneous, 5-fluoro-orotate… (More)

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@article{Bell2002LossOG, title={Loss of genetic accuracy in mutants of the thermoacidophile Sulfolobus acidocaldarius.}, author={Greg D. Bell and Dennis W. Grogan}, journal={Archaea}, year={2002}, volume={1 1}, pages={45-52} }