Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes.

@article{Izon1998LossOF,
  title={Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes.},
  author={David J. Izon and Sofia Rozenfeld and Sheri F.T. Fong and L{\'a}szl{\'o} G. K{\"o}m{\"u}ves and Corey Largman and Hugh Jeffrey Lawrence},
  journal={Blood},
  year={1998},
  volume={92 2},
  pages={383-93}
}
Hox homeobox genes play a crucial role in specifying the embryonic body pattern. However, a role for Hox genes in T-cell development has not been explored. The Hoxa-9 gene is expressed in normal adult and fetal thymuses. Fetal thymuses of mice homozygous for an interruption of the Hoxa-9 gene are one eighth normal size and have a 25-fold decrease in the number of primitive thymocytes expressing the interleukin-2 receptor (IL-2R, CD25). Progression to the double positive (CD4+CD8+) stage is… CONTINUE READING

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