Loss of function of KRE5 suppresses temperature sensitivity of mutants lacking mitochondrial anionic lipids.

@article{Zhong2005LossOF,
  title={Loss of function of KRE5 suppresses temperature sensitivity of mutants lacking mitochondrial anionic lipids.},
  author={Quan Zhong and Jelena Gvozdenovic-Jeremic and Paul Webster and Jingming Zhou and Miriam L Greenberg},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 2},
  pages={
          665-75
        }
}
Disruption of PGS1, which encodes the enzyme that catalyzes the committed step of cardiolipin (CL) synthesis, results in loss of the mitochondrial anionic phospholipids phosphatidylglycerol (PG) and CL. The pgs1Delta mutant exhibits severe growth defects at 37 degrees C. To understand the essential functions of mitochondrial anionic lipids at elevated temperatures, we isolated suppressors of pgs1Delta that grew at 37 degrees C. One of the suppressors has a loss of function mutation in KRE5… CONTINUE READING

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