Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

@article{Weiss2011LossoffunctionMI,
  title={Loss-of-function mutations in sodium channel Nav1.7 cause anosmia},
  author={Jan Weiss and Martina Pyrski and Eric Jacobi and Bernd Bufe and Vivienne Willnecker and Bernhard Schick and Philippe Zizzari and Samuel J. Gossage and Charles August Greer and Trese Leinders-Zufall and C Geoffrey Woods and John N Wood and Frank Zufall},
  journal={Nature},
  year={2011},
  volume={472},
  pages={186-190}
}
Loss of function of the gene SCN9A, encoding the voltage-gated sodium channel Nav1.7, causes a congenital inability to experience pain in humans. Here we show that Nav1.7 is not only necessary for pain sensation but is also an essential requirement for odour perception in both mice and humans. We examined human patients with loss-of-function mutations in SCN9A and show that they are unable to sense odours. To establish the essential role of Nav1.7 in odour perception, we generated conditional… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

15th Annual Meeting of the Safety Pharmacology Society: Focus on traditional sensory systems.

Journal of pharmacological and toxicological methods • 2017
View 4 Excerpts
Highly Influenced

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.

Proceedings of the National Academy of Sciences of the United States of America • 2013
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Age-induced disruption of selective olfactory bulb synaptic circuits.

Proceedings of the National Academy of Sciences of the United States of America • 2010

mammalian odor perception

A. Keller, Vosshall, L. B. Better smelling through genetics
Curr. Opin. Neurobiol. 18, 364–369 • 2008

Similar Papers

Loading similar papers…