Loss-of-function analysis of EphA receptors in retinotectal mapping.

@article{Feldheim2004LossoffunctionAO,
  title={Loss-of-function analysis of EphA receptors in retinotectal mapping.},
  author={David A Feldheim and Masaru Nakamoto and Miriam Osterfield and Nicholas Gale and Thomas M Dechiara and Rajat Rohatgi and George D. Yancopoulos and John G. Flanagan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 10},
  pages={2542-50}
}
EphA tyrosine kinases are thought to act as topographically specific receptors in the well-characterized projection map from the retina to the tectum. Here, we describe a loss-of-function analysis of EphA receptors in retinotectal mapping. Expressing patches of a cytoplasmically truncated EphA3 receptor in chick retina caused temporal axons to have reduced responsiveness to posterior tectal repellent activity in vitro and to shift more posteriorly within the map in vivo. A gene disruption of… CONTINUE READING

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